What is Cancer?
Cancer is a complex disease and occurs when cells in the body begin to grow chaotically. Normally,
cells grow, divide, and produce more cells to keep the body healthy and functioning properly.
Sometimes, however, the process goes astray; cells keep dividing when new cells are not needed.
Some types of cells are more prone to abnormal growth than others. The mass of extra cells forms
a growth or tumor, which can be benign or malignant.
Benign tumors are not cancer. They often can be removed and, in most cases, they
do not come back. Cells in benign tumors do not spread to other parts of the body. More
importantly, benign tumors are rarely life threatening.
Malignant tumors are cancer. Cells in malignant tumors are abnormal
and divide without control or order. These cancer cells can invade and destroy
the tissue around them. In a process called metastasis, cancerous cells break
away from the organs on which they are growing and travel to other parts of the
body, where they continue to grow. Cells from cancerous ovaries, for example,
commonly spread to the abdomen and nearby internal organs. Eventually, they travel
throughout the body by invading the two systems of vessels that bathe and feed all
of the body's organs; the bloodstream and lymph system.
Approximately 1,600,000 new cancer cases are diagnosed annually.
According to the American Cancer Society, approximately 570,000 Americans are expected
to die of cancer this year, more than 1,560 people per day.
PET/CT Scans and Cancer
Positron Emission Tomography (PET) and Computed Tomography (CT) imaging have become essential diagnostic tools physicians use to reveal the presence and severity of cancers. PET/CT imaging helps physicians detect cancer, evaluate the extent of disease, select the most appropriate treatments, determine if the therapy is working, and detect any recurrent tumors.
Before a PET/CT scan, the patient receives an intravenous injection of radioactive glucose. Many cancer cells are highly metabolic and rapidly synthesize the radioactive glucose. Information regarding the location of abnormal levels of radioactive glucose obtained from the whole-body PET/CT scan helps physicians effectively pinpoint the source of cancer and detect whether cancer is isolated to one specific area or has spread to other organs.
From this information physicians can plan an effective treatment strategy. Treatment options
include surgery, radiation therapy, systemic therapy, or a combination therapy where one or
more of these options are combined.
During the course of treatment, the information from the PET/CT scan allows
physicians to monitor the effectiveness of cancer therapies and provides physicians
with the opportunity to change the treatment strategy if it is not working, avoiding
the cost and discomfort of ineffective therapeutic procedures.
After completing the treatment regimen, a follow-up whole-body PET/CT scan can provide information
to assess if the treatment was successful and if areas that were previously abnormally metabolically
active have responded. Often, scar tissue at the site of surgical resection or radiation treatment may
appear as an abnormality on the CT scan. The PET portion of the PET/CT scan can detect residual disease
within the scar tissue and indicate if the treatment was successful or if the tumor has returned.
PET/CT scans provide information to help physicians:
- Locate the site of the cancer
- Determine the size of the tumor
- Differentiate benign from malignant growths
- Discover if the cancer has spread
- Select treatments that are likely to be appropriate
- Monitor the success of therapy
- Detect any recurrent tumors